High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma

Br J Surg. 2003 May;90(5):555-9. doi: 10.1002/bjs.4072.

Abstract

Background: Pancreatic metastases from renal cell carcinoma are rare but highly resectable. The aim of this study was to review a series of patients with this condition.

Methods: The study involved 22 consecutive patients with histologically proven pancreatic metastases from renal cell cancer.

Results: Seventeen of the 22 patients had surgery. No patient died but eight of the 17 patients had a postoperative complication. Median follow-up was 33 (range 1-96) months. The 24- and 60-month survival probabilities were 0.84 and 0.53 respectively. Five patients who did not undergo surgery had 24- and 60-month survival probabilities of 0.53 and 0.26 respectively. The difference between the two groups was significant (P = 0.040).

Conclusion: Despite the slow development of these secondaries and their well encapsulated morphology, the high rate of recurrence after limited resection suggests that radical resection should be recommended.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Renal Cell / secondary*
  • Carcinoma, Renal Cell / surgery*
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms / pathology
  • Kidney Neoplasms / surgery*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / etiology
  • Nephrectomy / methods
  • Pancreatectomy / methods
  • Pancreatic Neoplasms / secondary*
  • Pancreatic Neoplasms / surgery*
  • Pancreaticoduodenectomy / methods
  • RNA, Messenger / analysis
  • Tomography, X-Ray Computed

Substances

  • RNA, Messenger