Abstract
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Conserved Sequence
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Coronavirus / classification
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Coronavirus / genetics
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Coronavirus M Proteins
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Coronavirus Nucleocapsid Proteins
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DNA, Complementary
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Endopeptidases / chemistry
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Endopeptidases / genetics
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Genome, Viral*
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Humans
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Molecular Sequence Data
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Nucleocapsid Proteins / chemistry
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Nucleocapsid Proteins / genetics
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Open Reading Frames
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Phylogeny
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Polyproteins / chemistry
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Polyproteins / genetics
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Viral / genetics*
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RNA-Dependent RNA Polymerase / chemistry
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RNA-Dependent RNA Polymerase / genetics
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Regulatory Sequences, Nucleic Acid
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Sequence Analysis, DNA
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Severe Acute Respiratory Syndrome / virology
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Severe acute respiratory syndrome-related coronavirus / chemistry
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Severe acute respiratory syndrome-related coronavirus / classification
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Severe acute respiratory syndrome-related coronavirus / genetics*
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Severe acute respiratory syndrome-related coronavirus / isolation & purification
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Spike Glycoprotein, Coronavirus
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Transcription, Genetic
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Viral Envelope Proteins / chemistry
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Viral Envelope Proteins / genetics
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Viral Matrix Proteins / chemistry
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Viral Matrix Proteins / genetics
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Viral Proteins / chemistry
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Viral Proteins / genetics*
Substances
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Coronavirus M Proteins
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Coronavirus Nucleocapsid Proteins
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DNA, Complementary
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M protein, SARS-CoV
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Membrane Glycoproteins
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Nucleocapsid Proteins
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Polyproteins
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RNA, Messenger
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RNA, Viral
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins
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Viral Matrix Proteins
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Viral Proteins
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RNA-Dependent RNA Polymerase
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Endopeptidases