No mutation in the SLC2A2 ( GLUT2) gene in a Turkish infant with Fanconi-Bickel syndrome

Pediatr Nephrol. 2003 Apr;18(4):397-8. doi: 10.1007/s00467-003-1085-5. Epub 2003 Mar 11.

Abstract

Fanconi-Bickel syndrome (FBS), or glycogen storage disease type XI, is a rare, well-defined clinical entity. Recently, this disease was elucidated to link mutations in the SLC2A2 gene in many ethnic groups, indicating that FBS is a single gene disease. We report here an 8-month-old Turkish girl who developed characteristic findings of FBS. However, no mutation was detected in the protein-coding region of the SLC2A2 gene. Therefore, we propose that further molecular analysis is needed to determine whether other genes are involved in FBS.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Glucose Transporter Type 2
  • Glycogen Storage Disease / diagnosis
  • Glycogen Storage Disease / diet therapy
  • Glycogen Storage Disease / genetics*
  • Humans
  • Infant
  • Monosaccharide Transport Proteins / genetics*
  • Mutation / genetics*
  • Phosphorus / therapeutic use
  • Vitamin D / therapeutic use

Substances

  • Glucose Transporter Type 2
  • Monosaccharide Transport Proteins
  • Vitamin D
  • Phosphorus