Relationship between advanced glycoxidation end products, inflammatory markers/acute-phase reactants, and some autoantibodies in chronic hemodialysis patients

Kidney Int Suppl. 2003 May:(84):S62-4. doi: 10.1046/j.1523-1755.63.s84.19.x.

Abstract

Uremia and dialysis treatment are associated with uncorrected oxidative and carbonyl stress and microinflammation. Elevation of both oxidative/carbonyl stress end products (advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and advanced lipoperoxidation end products (ALEs), autoantibodies against modified biological structures, and acute-phase reactants (e.g., C-reactive protein [CRP], fibrinogen) seems to take part in the development of various complications, among them accelerated atherosclerosis. These pathogenic mechanisms are supposed to act synergically; nevertheless, oxidative stress shows a closer relationship to inflammation and acute-phase reaction than advanced glycation. Its end product, AOPP, could, thus, represent a biochemical marker of specific importance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute-Phase Proteins / immunology
  • Acute-Phase Proteins / metabolism*
  • Autoantibodies / immunology*
  • Biomarkers
  • Glycation End Products, Advanced / immunology
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Kidney Failure, Chronic / immunology*
  • Kidney Failure, Chronic / metabolism*
  • Kidney Failure, Chronic / therapy
  • Renal Dialysis

Substances

  • Acute-Phase Proteins
  • Autoantibodies
  • Biomarkers
  • Glycation End Products, Advanced