Transformation of a MGUS to overt multiple myeloma: the possible role of a pituitary macroadenoma secreting high levels of insulin-like growth factor 1 (IGF-1)

Leuk Lymphoma. 2003 Mar;44(3):543-5. doi: 10.1080/1042819021000037895.

Abstract

We present a female patient with monoclonal gammopathy of undetermined significance who has remained stable for five years but evolved to overt myeloma in strict temporal relationship with the diagnosis of GH-secreting pituitary macroadenoma. IGF-I serum levels correlated with serum and urine M component. Since the in vitro role of IGF-I on proliferation and survival of normal and neoplastic plasma cells has been recently emphasized, the pathogenetic link between acromegaly and transformation of gammopathy to overt myeloma in this case is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / drug therapy
  • Adenoma / metabolism*
  • Adenoma / radiotherapy
  • Aged
  • Cell Survival
  • Combined Modality Therapy
  • Disease Progression
  • Fatal Outcome
  • Female
  • Human Growth Hormone / metabolism
  • Humans
  • Insulin-Like Growth Factor I / metabolism*
  • Multiple Myeloma / etiology*
  • Myeloma Proteins / analysis
  • Neoplasms, Multiple Primary*
  • Octreotide / therapeutic use
  • Paraproteinemias / complications*
  • Peptides, Cyclic / therapeutic use
  • Pituitary Neoplasms / drug therapy
  • Pituitary Neoplasms / metabolism*
  • Pituitary Neoplasms / radiotherapy
  • Plasma Cells / pathology
  • Somatostatin / analogs & derivatives*
  • Somatostatin / therapeutic use

Substances

  • Myeloma Proteins
  • Peptides, Cyclic
  • lanreotide
  • Human Growth Hormone
  • Somatostatin
  • Insulin-Like Growth Factor I
  • Octreotide