Azalide 3,6-ketals: antibacterial activity and structure-activity relationships of aryl and hetero aryl substituted analogues

Subas M Sakya; Peter Bertinato; Bryan Pratt; Melani Suarez-Contreras; Kristin M Lundy; Martha L Minich; Hengmiao Cheng; Carl B Ziegler; Barbara J Kamicker; Shigeru F Hayashi; Sheryl L Santoro; David M George; Camilla D Bertsche

doi:10.1016/s0960-894x(03)00100-8

Azalide 3,6-ketals: antibacterial activity and structure-activity relationships of aryl and hetero aryl substituted analogues

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1373-5. doi: 10.1016/s0960-894x(03)00100-8.

Authors

Subas M Sakya¹, Peter Bertinato, Bryan Pratt, Melani Suarez-Contreras, Kristin M Lundy, Martha L Minich, Hengmiao Cheng, Carl B Ziegler, Barbara J Kamicker, Shigeru F Hayashi, Sheryl L Santoro, David M George, Camilla D Bertsche

Affiliation

¹ Veterinary Medicine Research and Development, Pfizer Inc, Groton, CT 06340, USA. sakyas@groton.pfizer.com

PMID: 12657285
DOI: 10.1016/s0960-894x(03)00100-8

Abstract

Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity against veterinary pathogens, including Staphylococcus aureus and Pasteurella multocida.

MeSH terms

Animals
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Cattle
Cattle Diseases / microbiology
Female
Gonadotropin-Releasing Hormone / analogs & derivatives*
Gonadotropin-Releasing Hormone / chemical synthesis
Gonadotropin-Releasing Hormone / pharmacology*
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / pharmacology*
Mastitis, Bovine / microbiology
Mice
Microbial Sensitivity Tests
Pasteurella multocida / drug effects
Pasteurellosis, Pneumonic / microbiology
Staphylococcus aureus / drug effects
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Heterocyclic Compounds
Gonadotropin-Releasing Hormone