Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia

Cancer Genet Cytogenet. 2003 Jan 15;140(2):153-6. doi: 10.1016/s0165-4608(02)00642-8.

Abstract

A rare chromosomal translocation, (11;20)(p15;q11), was detected in a 29-year-old male patient diagnosed with acute monocytic leukemia (AMoL) according to the French-American-British classification criteria. Whole chromosome painting analysis with paints for chromosomes 11 and 20 confirmed the result of conventional cytogenetic analysis. Reverse transcriptase polymerase chain reaction revealed the NUP98-TOP1 fusion transcript. To our knowledge, this is the second report of the translocation involving NUP98 and TOP1 genes in AMoL. On reviewing the literature, we suggest that t(11;20)(p15q11) is associated with myelocytic disorders rather than lymphocytic proliferative diseases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Chromosome Painting
  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 11 / ultrastructure
  • Chromosomes, Human, Pair 20 / genetics*
  • Chromosomes, Human, Pair 20 / ultrastructure
  • DNA Topoisomerases, Type I / genetics*
  • Fatal Outcome
  • Humans
  • Leukemia, Monocytic, Acute / genetics*
  • Leukemia, Monocytic, Acute / pathology
  • Lymphocytes / pathology
  • Male
  • Molecular Sequence Data
  • Myeloid Cells / pathology
  • Neoplasm Proteins / genetics*
  • Nuclear Pore Complex Proteins / genetics*
  • Oncogene Proteins, Fusion / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Translocation, Genetic / genetics*

Substances

  • NUP98-TOP1 fusion protein, human
  • Neoplasm Proteins
  • Nuclear Pore Complex Proteins
  • Nup98 protein, human
  • Oncogene Proteins, Fusion
  • DNA Topoisomerases, Type I