Abstract
The inhibitor of apoptosis (IAP) gene family prevents cell death by binding to and inhibiting caspases. In addition to negatively regulating apoptosis, IAPs bind to signaling intermediates and receptors, and participate in diverse cellular functions. Here, we describe the physiological functions of IAPs and their participation in injury and disease processes.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Apoptosis*
-
Disease Models, Animal
-
Humans
-
Inhibitor of Apoptosis Proteins
-
Microtubule-Associated Proteins / physiology
-
Models, Biological
-
Multigene Family
-
Neoplasm Proteins
-
Neoplasms / metabolism
-
Nerve Tissue Proteins / physiology
-
Neuronal Apoptosis-Inhibitory Protein
-
Neurons / metabolism
-
Protein Biosynthesis
-
Protein Structure, Tertiary
-
Proteins / metabolism
-
Proteins / physiology*
-
Signal Transduction
-
Survivin
-
Transcription, Genetic
-
Transforming Growth Factor beta
-
X-Linked Inhibitor of Apoptosis Protein
Substances
-
BIRC5 protein, human
-
Inhibitor of Apoptosis Proteins
-
Microtubule-Associated Proteins
-
NAIP protein, human
-
Neoplasm Proteins
-
Nerve Tissue Proteins
-
Neuronal Apoptosis-Inhibitory Protein
-
Proteins
-
Survivin
-
Transforming Growth Factor beta
-
X-Linked Inhibitor of Apoptosis Protein
-
XIAP protein, human