A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

N Engl J Med. 2003 Jan 16;348(3):255-6. doi: 10.1056/NEJM200301163480314.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, X
  • DNA-Binding Proteins / genetics*
  • Gene Expression
  • Genetic Linkage
  • Genetic Therapy / adverse effects*
  • Humans
  • LIM Domain Proteins
  • Lymphocyte Count
  • Metalloproteins / genetics*
  • Mutagenesis, Insertional*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
  • Proto-Oncogene Proteins
  • Retroviridae
  • Severe Combined Immunodeficiency / therapy*

Substances

  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • LIM Domain Proteins
  • LMO2 protein, human
  • Metalloproteins
  • Proto-Oncogene Proteins