A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta-lactamase: an emerging concern in pediatrics?

Microb Drug Resist. 2002 Winter;8(4):329-33. doi: 10.1089/10766290260469598.

Abstract

A 5-year-old child was colonized by an isolate of Escherichia coli that transferred resistance to third-generation cephalosporins and cefoxitin. This resistance phenotype was encoded on a >75-kb plasmid pLRM 22. The transferable plasmid contained both blaCMY-2 and blaTEM-1b. Increasing reports of CMY-2 beta-lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Proteins*
  • Child
  • Child, Preschool
  • Colony Count, Microbial
  • Conjugation, Genetic
  • DNA, Bacterial / genetics
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Escherichia coli Infections / microbiology*
  • Female
  • Humans
  • Isoelectric Focusing
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • AmpC beta-lactamases
  • beta-Lactamases