Abstract
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adjuvants, Immunologic / therapeutic use
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Antibodies, Monoclonal / therapeutic use
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Antigen Presentation
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Antigens, Neoplasm / immunology
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Humans
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Immunotherapy*
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Killer Cells, Lymphokine-Activated / immunology
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Lymphocytes, Tumor-Infiltrating / immunology
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Neoplasms / genetics
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Neoplasms / immunology
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Neoplasms / therapy*
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Receptors, Antigen, T-Cell / immunology
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T-Lymphocytes / immunology*
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T-Lymphocytes, Regulatory / immunology
Substances
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Adjuvants, Immunologic
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Antibodies, Monoclonal
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Antigens, Neoplasm
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Receptors, Antigen, T-Cell