Abstract
In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Bacterial / blood
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Bacterial Proteins / administration & dosage
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / immunology
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Bacteroidaceae Infections / prevention & control
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Cysteine Endopeptidases / administration & dosage
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Cysteine Endopeptidases / chemistry*
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Cysteine Endopeptidases / genetics
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Cysteine Endopeptidases / immunology*
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Disease Models, Animal
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Hemoglobins / metabolism
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Immunization
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Immunoglobulin G / blood
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Immunoglobulin G / classification
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Periodontitis / prevention & control*
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Porphyromonas gingivalis / immunology*
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Rats
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Rats, Inbred F344
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Recombinant Proteins / immunology
Substances
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Antibodies, Bacterial
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Bacterial Proteins
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Bacterial Vaccines
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Hemoglobins
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Immunoglobulin G
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Recombinant Proteins
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Cysteine Endopeptidases
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gingivain