Liposarcoma is the second sarcoma of soft tissues more frequent in adult-age. Its localisation in head and neck is odd. The majority of liposarcoma, of this sitting, take its origin from soft tissues of the neck, being unusual primary liposarcoma from larynx and hypolarynx. Presentation of one case of liposarcoma of the larynx and hypopharynx and review of the opportune literature.