Rotavirus gastroenteritis and central nervous system (CNS) infection: characterization of the VP7 and VP4 genes of rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease

J Clin Microbiol. 2002 Dec;40(12):4797-9. doi: 10.1128/JCM.40.12.4797-4799.2002.

Abstract

Rotavirus RNA was detected in the cerebrospinal fluid (CSF) of a child with central nervous system disease symptoms associated with rotavirus gastroenteritis. The rotavirus isolates from the fecal and CSF samples were genotyped as G1P[8]. Sequence analysis of the VP7 and VP4 proteins derived from the fecal and CSF samples were remarkably similar to each other and to G1P[8] rotavirus strains commonly circulating in the community and associated with gastroenteritis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral*
  • Capsid Proteins / genetics*
  • Central Nervous System Viral Diseases / virology*
  • Cerebrospinal Fluid / virology
  • Feces / virology
  • Gastroenteritis / virology*
  • Genotype
  • Humans
  • Infant
  • Male
  • Rotavirus / classification
  • Rotavirus / genetics
  • Rotavirus / isolation & purification*
  • Rotavirus Infections / virology
  • Sequence Analysis, DNA

Substances

  • Antigens, Viral
  • Capsid Proteins
  • VP4 protein, Rotavirus
  • VP7 protein, Rotavirus