Abstract
In this issue of Neuron, Zhang and Poo present evidence for localized BDNF-induced synaptic potentiation that is accompanied by spatially restricted calcium influx and requires local axonal protein synthesis. These results are consistent with a synapse-specific role for BDNF and provide a potentially novel way to think about cellular mechanisms for potentiation of neurotransmitter release.
MeSH terms
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Animals
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Brain-Derived Neurotrophic Factor / metabolism*
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Brain-Derived Neurotrophic Factor / pharmacology
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Calcium Signaling / drug effects
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Calcium Signaling / physiology
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Humans
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Nervous System / drug effects
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Nervous System / metabolism*
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Neuromuscular Junction / drug effects
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Neuromuscular Junction / metabolism*
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Neurotransmitter Agents / metabolism*
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Presynaptic Terminals / drug effects
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Presynaptic Terminals / metabolism
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Receptor, trkB / antagonists & inhibitors
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Receptor, trkB / metabolism
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology*
Substances
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Brain-Derived Neurotrophic Factor
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Neurotransmitter Agents
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Receptor, trkB