Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals

J Virol. 2002 Dec;76(23):12344-8. doi: 10.1128/jvi.76.23.12344-12348.2002.

Abstract

We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antigens, Viral / genetics
  • Antiretroviral Therapy, Highly Active
  • Base Sequence
  • Evolution, Molecular*
  • Genes, env
  • Genetic Variation
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • HIV-1 / immunology
  • Humans
  • Molecular Sequence Data
  • RNA, Viral / blood
  • RNA, Viral / genetics

Substances

  • Antigens, Viral
  • RNA, Viral

Associated data

  • GENBANK/UNKNOWN