Methodologic issues in epidemiologic studies of congenital microcephaly

Alan Leviton; Lewis B Holmes; Elizabeth N Allred; Juan Vargas

doi:10.1016/s0378-3782(02)00065-8

Methodologic issues in epidemiologic studies of congenital microcephaly

Early Hum Dev. 2002 Oct;69(1-2):91-105. doi: 10.1016/s0378-3782(02)00065-8.

Authors

Alan Leviton¹, Lewis B Holmes, Elizabeth N Allred, Juan Vargas

Affiliation

¹ Department of Neurology, Harvard Medical School and Children's Hospital, Neuroepidemiology Unit, Boston, MA 02115-5724, USA. alan.leviton@tch.harvard.edu

PMID: 12324187
DOI: 10.1016/s0378-3782(02)00065-8

Abstract

In this methodological paper, we explore a number of issues that pose problems for those who seek the antecedents of congenital microcephaly. We pay particular attention to three concerns: Who is a case? How should cases be classified? To whom should cases be compared?

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Epidemiologic Methods*
Female
Fetal Growth Retardation
Gestational Age
Head / embryology
Head / growth & development
Humans
Infant, Newborn
Male
Microcephaly / embryology
Microcephaly / epidemiology*
Microcephaly / pathology

Grants and funding

NS26093/NS/NINDS NIH HHS/United States