CT angiography (CTA) is based on acquisition of data during the arterial phase of contrast material passage. CTA needs timing of the contrast bolus, which should be based on accurate knowledge of bolus geometry. Experimental and human studies on bolus geometry and bolus timing in CTA were reviewed. Important parameters of bolus geometry and methods of bolus timing (test bolus and bolus tracking) are described. Recommendations are given for an optimal CTA protocol.