Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone

Vibha Mishra; S N Pandeya; Christophe Pannecouque; Myriam Witvrouw; E De Clercq

doi:10.1002/1521-4184(200205)335:5<183::AID-ARDP183>3.0.CO;2-U

Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone

Arch Pharm (Weinheim). 2002 May;335(5):183-6. doi: 10.1002/1521-4184(200205)335:5<183::AID-ARDP183>3.0.CO;2-U.

Authors

Vibha Mishra¹, S N Pandeya, Christophe Pannecouque, Myriam Witvrouw, E De Clercq

Affiliation

¹ Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, India.

PMID: 12210774
DOI: 10.1002/1521-4184(200205)335:5<183::AID-ARDP183>3.0.CO;2-U

Abstract

A series of thiosemicarbazones and semicarbazone derivatives of (+/-)-3-menthone have been synthesized and their anti-HIV activity evaluated against HIV-1(III(B))and HIV-2 (ROD). The studies revealed that maximum protection is offered by chloro-substituted derivatives 2 and 7 against HIV-1 (III(B)) and HIV-2 (ROD).

MeSH terms

Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / pharmacology*
HIV-1 / drug effects
HIV-2 / drug effects
Humans
Menthol / chemical synthesis*
Menthol / pharmacology*
Semicarbazones / chemical synthesis*
Semicarbazones / pharmacology
Structure-Activity Relationship
Thiosemicarbazones / chemical synthesis*
Thiosemicarbazones / pharmacology

Substances

Anti-HIV Agents
Semicarbazones
Thiosemicarbazones
Menthol
menthone