Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae

Antimicrob Agents Chemother. 2002 Sep;46(9):3094-5. doi: 10.1128/AAC.46.9.3094-3095.2002.

Abstract

The activity of AZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 micro g/ml and 0.5 and 1 micro g/ml, respectively, for the two isolate groups. These MICs were within 1 log(2) dilution of those of linezolid.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Microbial
  • Humans
  • Linezolid
  • Microbial Sensitivity Tests
  • North America
  • Oxazolidinones / pharmacology*
  • Pneumococcal Infections / microbiology
  • Streptococcus pneumoniae / drug effects*

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • posizolid
  • Linezolid