A novel strategy for the synthesis of medium-sized lactams

Hans Bieräugel; T Paul Jansen; Hans E Schoemaker; Henk Hiemstra; Jan H van Maarseveen

doi:10.1021/ol0261579

A novel strategy for the synthesis of medium-sized lactams

Org Lett. 2002 Aug 8;4(16):2673-4. doi: 10.1021/ol0261579.

Authors

Hans Bieräugel¹, T Paul Jansen, Hans E Schoemaker, Henk Hiemstra, Jan H van Maarseveen

Affiliation

¹ Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, The Netherlands.

PMID: 12153206
DOI: 10.1021/ol0261579

Abstract

[reaction: see text] A novel method for the synthesis of medium-sized lactams based on an auxiliary-mediated combined tethered/templated strategy is presented. Cyclization by a tethered ring-closing metathesis reaction was followed by a templated transannular aminolysis reaction to give seven- to ten-membered lactams in good yields.