Abstract
After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.
Publication types
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Clinical Trial
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-HIV Agents / administration & dosage*
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Anti-HIV Agents / therapeutic use
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Antiretroviral Therapy, Highly Active*
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / pathology*
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Female
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Genotype
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HIV / drug effects
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HIV / genetics
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HIV / isolation & purification
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HIV / physiology
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HIV Infections / drug therapy*
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HIV Infections / immunology*
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HIV Infections / virology
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Humans
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Lamivudine / administration & dosage
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Lamivudine / therapeutic use
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Male
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Mutation / genetics
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RNA, Viral / analysis
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Time Factors
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Viral Load
Substances
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Anti-HIV Agents
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RNA, Viral
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Lamivudine