Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and detection of viral antigen in the hypophysis

Clin Infect Dis. 2002 Jul 1;35(1):96-101. doi: 10.1086/340859. Epub 2002 Jun 6.

Abstract

We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Viral / analysis*
  • Hemorrhage / diagnosis*
  • Hemorrhage / etiology
  • Hemorrhage / virology
  • Hemorrhagic Fever with Renal Syndrome / diagnosis*
  • Hemorrhagic Fever with Renal Syndrome / physiopathology
  • Humans
  • Hypopituitarism / diagnosis*
  • Hypopituitarism / etiology
  • Hypopituitarism / virology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Pituitary Diseases / diagnosis
  • Pituitary Diseases / etiology
  • Pituitary Diseases / virology
  • Pituitary Gland / virology*
  • Puumala virus*

Substances

  • Antigens, Viral