[Urinary antimicrobial prophylaxis]

Arch Pediatr. 2002 May;9(5):511-8. doi: 10.1016/s0929-693x(01)00835-1.
[Article in French]

Abstract

Antibiotics are usually used to prevent childhood recurrent urinary tract infections: cystitis or pyelonephritis. The mechanism of action of these antibiotics, although imperfectly known, seems to be double: the antibiotic acts by its bactericidal effect, but also probably for minimal concentrations by reducing adhesion capability of bacteria to the urothelium. The most commonly used molecules are cotrimoxazole, trimethoprime, pivmecillinam, cefaclor and nalidixic acid. However all have not been studied rigorously as for their prophylactic capacity, and in particular very little is known for patients presenting with vesico-ureteral reflux.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Amdinocillin Pivoxil / administration & dosage
  • Anti-Infective Agents, Urinary / administration & dosage*
  • Antibiotic Prophylaxis*
  • Cefaclor / administration & dosage
  • Child
  • Cystitis / microbiology
  • Cystitis / prevention & control*
  • Humans
  • Pyelonephritis / microbiology
  • Pyelonephritis / prevention & control*
  • Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage

Substances

  • Anti-Infective Agents, Urinary
  • Amdinocillin Pivoxil
  • Cefaclor
  • Trimethoprim, Sulfamethoxazole Drug Combination