A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues

Org Lett. 2002 Jun 13;4(12):2091-3. doi: 10.1021/ol020073i.

Abstract

[structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.

MeSH terms

  • Enzyme Inhibitors / chemical synthesis*
  • IMP Dehydrogenase / antagonists & inhibitors*
  • Oxazoles / chemical synthesis*
  • Oxazoles / chemistry

Substances

  • Enzyme Inhibitors
  • Oxazoles
  • IMP Dehydrogenase
  • BMS-337197