Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1637-41. doi: 10.1016/s0960-894x(02)00217-2.

Abstract

Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Circular Dichroism
  • Cyclodextrins / chemistry
  • Cyclodextrins / pharmacology*
  • Models, Molecular*
  • Paclitaxel / chemistry
  • Paclitaxel / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Cyclodextrins
  • Paclitaxel