Linkage analysis in a large family with primary pulmonary hypertension: genetic heterogeneity and a second primary pulmonary hypertension locus on 2q31-32

Chest. 2002 Mar;121(3 Suppl):54S-56S. doi: 10.1378/chest.121.3_suppl.54s.

Authors

Bart Janssen¹, Matthias Rindermann, Ulrike Barth, Gabriel Miltenberger-Miltenyi, Derliz Mereles, Adel Abushi, Werner Seeger, Wolfgang Kübler, Claus R Bartram, Ekkehard Grünig

Affiliation

¹ Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany. Bart_Janssen@med.uni-heidelberg.de

PMID: 11893685
DOI: 10.1378/chest.121.3_suppl.54s

No abstract available

MeSH terms

Bone Morphogenetic Protein 2
Bone Morphogenetic Protein Receptors, Type II
Bone Morphogenetic Proteins / genetics
Chromosome Mapping*
Chromosomes, Human, Pair 2*
Echocardiography, Doppler
Echocardiography, Stress
Genetic Heterogeneity*
Genetic Linkage*
Genotype
Heterozygote
Humans
Hypertension, Pulmonary / diagnosis
Hypertension, Pulmonary / genetics*
Lod Score
Mutation
Pedigree
Protein Serine-Threonine Kinases / genetics
Transforming Growth Factor beta*

Substances

BMP2 protein, human
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Transforming Growth Factor beta
Protein Serine-Threonine Kinases
BMPR2 protein, human
Bone Morphogenetic Protein Receptors, Type II