Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivation

Methods Enzymol. 2002:348:297-305. doi: 10.1016/s0076-6879(02)48648-x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 4-Chloro-7-nitrobenzofurazan
  • Catalytic Domain
  • Cell Line
  • Cysteine / chemistry
  • Enzyme Inhibitors / pharmacology
  • Epidermal Growth Factor / pharmacology
  • Glutathione / metabolism
  • Humans
  • Hydrogen Peroxide / pharmacology
  • Hydrogen-Ion Concentration
  • Kinetics
  • Models, Biological
  • Oxidation-Reduction
  • Protein Tyrosine Phosphatases / antagonists & inhibitors
  • Protein Tyrosine Phosphatases / chemistry*
  • Protein Tyrosine Phosphatases / metabolism*
  • Signal Transduction
  • Sulfenic Acids / chemistry

Substances

  • Enzyme Inhibitors
  • Sulfenic Acids
  • Epidermal Growth Factor
  • Hydrogen Peroxide
  • Protein Tyrosine Phosphatases
  • 4-Chloro-7-nitrobenzofurazan
  • Glutathione
  • Cysteine