Abstract
We have previously described postentry restriction of murine leukemia virus in mammals. Here we characterize the block in human cells. Restricted infection kinetics are multiple hit at high virus dose, and restriction is abrogated by preexposure to restricted virus. We hypothesize that restricted capsid can titrate out the restriction factor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Capsid / genetics
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Capsid / metabolism
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Cell Line
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Genetic Vectors
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Humans
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Leukemia Virus, Murine / genetics
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Leukemia Virus, Murine / pathogenicity*
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Leukemia Virus, Murine / physiology
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Leukemia, Experimental / virology
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Mice
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Proteins / genetics*
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Proteins / metabolism
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Retroviridae Infections / virology
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Tumor Virus Infections / virology