The utility of Bayesian model averaging for detecting known oligogenic effects

Genet Epidemiol. 2001:21 Suppl 1:S789-93. doi: 10.1002/gepi.2001.21.s1.s789.

Abstract

In this paper we examine the utility of the Bayesian model averaging approach proposed by Blangero et al. [Genet Epidemiol 17(Suppl. 1):S67-72, 1999] for the detection of known oligogenic effects on quantitative trait 1 (Q1) in the simulated Genetic Analysis Workshop 12 data. The results were consistent with the underlying genetic model: two major QTLs were identified on chromosomes 19 and 2, with heritabilities of 17% and 20%, respectively, located near the position of major genes 1 and 2.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Bayes Theorem
  • Chromosome Mapping / statistics & numerical data*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Lod Score
  • Models, Genetic*
  • Quantitative Trait, Heritable*