Objective. To put a mathematical model for predicting human somatic eigenstates (HS) into practical engineering design of countermeasures against combined stresses (hypoxia, heat, noise and vibration) in an aircraft cabin, and confirm the model from the human physiological viewpoint. Method. Published works on these 4 stresses were employed to verify the main and interactive effects which had been previously proved mathematically. Result. The main effects of 4 stresses and the significant interactive effects of 2 from 4 stresses agreed with the published experiments in single or in the same combination of these stresses. Conclusion. The model is reasonable in human physiological consideration and has been adopted in engineering design.