Abstract
Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean alpha-mannosidase to produce 7-O-alpha-D-mannopyranosyl-lincomycin (2).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides
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Anti-Bacterial Agents / chemistry*
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Aspergillus / enzymology
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Chemical Phenomena
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Chemistry, Physical
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Fabaceae / enzymology
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Glycosylation
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Lincomycin / chemistry*
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Magnetic Resonance Spectroscopy
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Mannose / chemistry
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Mannosidases / chemistry
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Spectrometry, Mass, Electrospray Ionization
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alpha-Mannosidase
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Lincomycin
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Mannosidases
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alpha-Mannosidase
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Mannose