Enzymatic glycosylation of lincomycin

Biosci Biotechnol Biochem. 2001 Aug;65(8):1897-9. doi: 10.1271/bbb.65.1897.

Abstract

Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean alpha-mannosidase to produce 7-O-alpha-D-mannopyranosyl-lincomycin (2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / chemistry*
  • Aspergillus / enzymology
  • Chemical Phenomena
  • Chemistry, Physical
  • Fabaceae / enzymology
  • Glycosylation
  • Lincomycin / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mannose / chemistry
  • Mannosidases / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • alpha-Mannosidase

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Lincomycin
  • Mannosidases
  • alpha-Mannosidase
  • Mannose