Stereospecific synthesis of trans-arachidonic acids

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2415-8. doi: 10.1016/s0960-894x(01)00442-5.

Abstract

An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 8,11,14-Eicosatrienoic Acid / analogs & derivatives*
  • 8,11,14-Eicosatrienoic Acid / chemistry
  • Arachidonic Acid / chemical synthesis*
  • Arachidonic Acid / chemistry
  • Biochemistry / methods*
  • Chromatography, High Pressure Liquid / methods
  • Magnetic Resonance Spectroscopy
  • Stereoisomerism

Substances

  • Arachidonic Acid
  • 11,12-epoxy-5,8,14-eicosatrienoic acid
  • 5,6-epoxy-8,11,14-eicosatrienoic acid
  • 8,9-epoxyeicosatrienoic acid
  • 14,15-epoxy-5,8,11-eicosatrienoic acid
  • 8,11,14-Eicosatrienoic Acid