No association between a promoter dopamine D(4) receptor gene variant and schizophrenia

Am J Med Genet. 2001 Aug 8;105(6):525-8. doi: 10.1002/ajmg.1478.

Abstract

The dopamine D(4) receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D(4) receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 - 521C/T polymorphism. No significant case control differences emerged. The present results do not support a major role for DRD4 in the etiology of schizophrenia among Caucasians from Sweden.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Alleles
  • DNA / genetics
  • Female
  • Gene Frequency
  • Genetic Variation
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Promoter Regions, Genetic / genetics*
  • Receptors, Dopamine D2 / genetics*
  • Receptors, Dopamine D4
  • Schizophrenia / genetics*

Substances

  • DRD4 protein, human
  • Receptors, Dopamine D2
  • Receptors, Dopamine D4
  • DNA