Amino acid catabolism in cheese-related bacteria: selection and study of the effects of pH, temperature and NaCl by quadratic response surface methodology

J Appl Microbiol. 2001 Aug;91(2):312-21. doi: 10.1046/j.1365-2672.2001.01405.x.

Abstract

Aims: To screen the cystathionine lyase and L-methionine aminotransferase activities of cheese-related bacteria (lactococci, non-starter lactobacilli and smear bacteria) and to determine the individual and interactive effects of temperature, pH and NaCl concentration on selected enzyme activities.

Methods and results: A subcellular fractionation protocol and specific enzyme assays were used, and a quadratic response surface methodology was applied. The majority of the strains, 21 of 33, had detectable cystathionine lyase activity which differed in the specificity. Aminotransferase activity on L-methionine was observed in only three strains. The cystathionine lyase activities of Lactobacillus reuteri DSM20016, Lactococcus lactis subsp. cremoris MG1363, Brevibacterium linens 10 and Corynebacterium ammoniagenes 8 and the L-methionine aminotransferase activity of Lact. reuteri DSM20016 had temperature and pH optima of 30-45 degrees C, and 7.5-8.0, respectively. As shown by the quadratic response surface methodology these enzymes retained activities in the range of temperature, pH and NaCl concentration which characterized the cheeses from which the bacteria originated.

Conclusion: The enzyme activities may have a role in flavour development during cheese ripening.

Significance and impact of the study: The findings of this work contribute to the knowledge about the amino acid catabolic enzymes in order to improve cheese ripening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / metabolism
  • Bacteria / cytology
  • Bacteria / drug effects
  • Bacteria / enzymology*
  • Bacteria / metabolism
  • Cheese / microbiology*
  • Corynebacterium / cytology
  • Corynebacterium / drug effects
  • Corynebacterium / enzymology
  • Corynebacterium / metabolism
  • Flavoring Agents
  • Hydrogen-Ion Concentration
  • Lactobacillus / cytology
  • Lactobacillus / drug effects
  • Lactobacillus / enzymology
  • Lactobacillus / metabolism
  • Lactococcus / cytology
  • Lactococcus / drug effects
  • Lactococcus / enzymology
  • Lactococcus / metabolism
  • Lyases / metabolism*
  • Osmolar Concentration
  • Sodium Chloride / pharmacology*
  • Temperature
  • Transaminases / metabolism*

Substances

  • Amino Acids
  • Flavoring Agents
  • Sodium Chloride
  • Transaminases
  • glutamine-pyruvate aminotransferase
  • Lyases
  • cystathionine beta-lyase