Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation

Blood. 2001 Jul 15;98(2):489-91. doi: 10.1182/blood.v98.2.489.

Abstract

In 93 allograft recipients, the numbers of marrow B-cell precursors on days 80 and 365 correlated with the counts of circulating B cells, suggesting that the posttransplantation B-cell deficiency is at least in part due to insufficient B lymphopoiesis. Factors that could affect B lymphopoiesis were evaluated. The number of marrow B-cell precursors on days 30 and 80 was at least 4-fold lower in patients with grade 2 to 4 acute graft-versus-host disease (GVHD) compared with patients with grade 0 to 1 acute GVHD. The number of B-cell precursors on day 365 was 18-fold lower in patients with extensive chronic GVHD compared with patients with no or limited chronic GVHD. The number of B-cell precursors was not related to CD34 cell dose, type of transplant (marrow versus blood stem cells), donor age, or patient age. It was concluded that posttransplantation B-cell deficiency results in part from inhibition of B lymphopoiesis by GVHD and/or its treatment.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • B-Lymphocytes*
  • Bone Marrow Cells / pathology
  • Bone Marrow Transplantation
  • Cell Count
  • Chronic Disease
  • Female
  • Graft vs Host Disease / pathology
  • Hematopoiesis*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Lymphocyte Count
  • Male
  • Middle Aged