Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior

Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):76S-81S. doi: 10.1097/00000374-200105051-00014.

Abstract

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cepsilon-regulated sensitivity of gamma-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor gamma2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Kari J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence / drug effects
  • Amino Acid Sequence / genetics
  • Animals
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology
  • Binding Sites / drug effects
  • Binding Sites / genetics
  • Central Nervous System Depressants / pharmacology*
  • Ethanol / pharmacology*
  • GABA Agonists / pharmacology
  • Humans
  • Isoenzymes / drug effects
  • Isoenzymes / genetics
  • Mice
  • Mutation / drug effects*
  • Mutation / genetics
  • Protein Kinase C / drug effects
  • Protein Kinase C / genetics
  • Protein Kinase C-epsilon
  • Receptors, GABA-A / drug effects*
  • Receptors, GABA-A / genetics
  • Receptors, Glycine / drug effects
  • Receptors, Glycine / genetics

Substances

  • Central Nervous System Depressants
  • GABA Agonists
  • Isoenzymes
  • Receptors, GABA-A
  • Receptors, Glycine
  • Ethanol
  • Prkce protein, mouse
  • PRKCE protein, human
  • Protein Kinase C
  • Protein Kinase C-epsilon