Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice

Transplant Proc. 2001 May;33(3):2094-5. doi: 10.1016/s0041-1345(01)01961-3.

Authors

C Gysemans¹, M Waer, J Laureys, R Bouillon, C Mathieu

Affiliation

¹ Department of Experimental Medicine and Endocrinology (LEGENDO), Catholic University of Leuven, Campus Gaithuisberg, Leuven, Belgium.

PMID: 11377464
DOI: 10.1016/s0041-1345(01)01961-3

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes
Animals
Cyclosporine / therapeutic use*
Diabetes Mellitus, Type 1 / surgery*
Drug Synergism
Graft Rejection / immunology
Graft Rejection / prevention & control*
Immunosuppressive Agents / therapeutic use*
Islets of Langerhans Transplantation / immunology*
Isoxazoles / therapeutic use*
Leflunomide
Mice
Mice, Inbred NOD
Nitriles / therapeutic use*
Rats
Transplantation, Heterologous / immunology*

Substances

Alkynes
Immunosuppressive Agents
Isoxazoles
Nitriles
2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide
Cyclosporine
Leflunomide