Abstract
Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Breast Neoplasms
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Cell Survival / drug effects*
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Commiphora
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Female
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Free Radical Scavengers / chemistry
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Gas Chromatography-Mass Spectrometry
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Plant Extracts / chemistry*
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Plant Gums
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Prostatic Neoplasms
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Rosales / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Free Radical Scavengers
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Indicators and Reagents
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Plant Extracts
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Plant Gums
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guggulu extract