Abstract
Most genes are members of a family. It is generally believed that a gene family derives from an ancestral gene by duplication and divergence. The tumor suppressor p53 was a striking exception to this established rule. However, two new p53 homologs, p63 and p73, have recently been described [1-6]. At the sequence level, p63 and p73 are more similar to each other than each is to p53, suggesting the possibility that the ancestral gene is a gene resembling p63/p73, while p53 is phylogenetically younger [1,2].The complexity of the family has also been enriched by the alternatively spliced forms of p63 and p73, which give rise to a complex network of proteins involved in the control of cell proliferation, apoptosis and development [1,2,4,7-9]. In this review we will mainly focus on similarities and differences as well as relationships among p63, p73 and p53.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Apoptosis
-
Carrier Proteins*
-
Cell Cycle Proteins*
-
DNA Damage
-
DNA-Binding Proteins / chemistry
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / metabolism*
-
E2F Transcription Factors
-
Evolution, Molecular*
-
Gene Deletion
-
Genes, Tumor Suppressor
-
Humans
-
Membrane Proteins*
-
Neoplasms / genetics
-
Neoplasms / metabolism
-
Nuclear Proteins / chemistry
-
Nuclear Proteins / genetics
-
Nuclear Proteins / metabolism*
-
Oncogene Proteins / metabolism
-
Phosphoproteins / chemistry
-
Phosphoproteins / genetics
-
Phosphoproteins / metabolism*
-
Protein Binding
-
Protein Isoforms / chemistry
-
Protein Isoforms / genetics
-
Protein Isoforms / metabolism
-
Retinoblastoma-Binding Protein 1
-
Trans-Activators*
-
Transcription Factor DP1
-
Transcription Factors / metabolism
-
Tumor Protein p73
-
Tumor Suppressor Protein p53 / chemistry
-
Tumor Suppressor Protein p53 / genetics
-
Tumor Suppressor Protein p53 / metabolism*
-
Tumor Suppressor Proteins
Substances
-
CKAP4 protein, human
-
Carrier Proteins
-
Cell Cycle Proteins
-
DNA-Binding Proteins
-
E2F Transcription Factors
-
Membrane Proteins
-
Nuclear Proteins
-
Oncogene Proteins
-
Phosphoproteins
-
Protein Isoforms
-
Retinoblastoma-Binding Protein 1
-
TP63 protein, human
-
TP73 protein, human
-
Trans-Activators
-
Transcription Factor DP1
-
Transcription Factors
-
Tumor Protein p73
-
Tumor Suppressor Protein p53
-
Tumor Suppressor Proteins