Abstract
CCR5 is the major coreceptor for human immunodeficiency virus (HIV) type 1 during primary infection. CCR5+ CD4 T lymphocytes were studied in subjects with primary HIV-1 infection (PHI) or acute Epstein-Barr virus (EBV) infection and in HIV-uninfected controls. The early decline of CD4 T lymphocytes during PHI resulted from depletion of CCR5- CD4 T lymphocytes. After antiretroviral therapy, Ki-67- CCR5- CD4 T cell counts rapidly increased in the circulation, which suggests that the initial decrease was due to an alteration in trafficking and/or sequestration. In the CCR5+ subset of CD4 T cells, there was an elevation in the proliferative (Ki-67+) fraction during PHI, yet their total number remained in the normal range. In contrast, in acute EBV infection, proliferating CCR5+ CD4 T cells accumulated to very high levels, suggesting they have an important role in the early antiviral response, which may be impaired in HIV-1 infection.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-HIV Agents / pharmacology
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Anti-HIV Agents / therapeutic use*
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism*
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Carbamates
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Dideoxynucleosides / pharmacology
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Dideoxynucleosides / therapeutic use
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Epstein-Barr Virus Infections / immunology
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Flow Cytometry
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Furans
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Genotype
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HIV Infections / drug therapy
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HIV Infections / immunology*
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HIV-1 / drug effects
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HIV-1 / genetics
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HIV-1 / immunology*
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Humans
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Immunoglobulin M / blood
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Lamivudine / pharmacology
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Lamivudine / therapeutic use
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Longitudinal Studies
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Male
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis
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Receptors, CCR5 / biosynthesis*
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Receptors, CCR5 / genetics
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Receptors, CCR5 / immunology
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Sulfonamides / pharmacology
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Sulfonamides / therapeutic use
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Time Factors
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Zidovudine / pharmacology
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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Carbamates
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Dideoxynucleosides
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Furans
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Immunoglobulin M
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Proto-Oncogene Proteins c-bcl-2
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Receptors, CCR5
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Sulfonamides
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Lamivudine
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Zidovudine
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amprenavir
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abacavir