Matrix metalloproteinases and TIMP-1 production by peripheral blood granulocytes from COPD patients and asthmatics

Allergy. 2001 Feb;56(2):145-51. doi: 10.1034/j.1398-9995.2001.056002145.x.

Abstract

Both asthmatic and COPD patients were found to have increased amounts of granulocytes and matrix metalloproteinase-9 (MMP-9) in their sputum. The present study was conducted to investigate whether the elevated amounts of MMP-9 and TIMP-1 found in such patients' airways may be linked to an enhanced secretion by granulocytes. Blood granulocytes from asthmatics (n = 10), COPD patients (n = 11), and healthy controls (n = 11) were isolated and cultured under basal conditions or after stimulation by phorbol 12-myristate 13-acetate (PMA) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). MMP-9 activity was detected by zymography while MMP-8 and TIMP-1 levels were measured by ELISA. In zymography, pro- and activated forms of MMP-9 were present in each group (healthy subjects, asthmatics, and COPD patients). Spontaneous release was not different between the three groups. Stimulation by fMLP and PMA increased to a similar extent the release of MMP-9 by granulocytes in all the three groups. TIMP-1 levels were also increased after stimulation by PMA and fMLP only in healthy subjects and COPD patients. MMP-8 levels were barely detectable. We conclude that circulating granulocytes from COPD patients and asthmatics do not display an abnormal secretion of MMP-9, and that granulocytes from asthmatics have an impaired ability to release TIMP-1 upon stimulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asthma / blood
  • Asthma / enzymology*
  • Female
  • Granulocytes / metabolism*
  • Humans
  • Lung Diseases, Obstructive / blood
  • Lung Diseases, Obstructive / enzymology*
  • Male
  • Matrix Metalloproteinase 8 / blood*
  • Matrix Metalloproteinase 8 / genetics
  • Matrix Metalloproteinase 9 / blood*
  • Matrix Metalloproteinase 9 / genetics
  • Middle Aged
  • RNA, Messenger / blood
  • Tissue Inhibitor of Metalloproteinase-1 / blood*
  • Tissue Inhibitor of Metalloproteinase-1 / genetics

Substances

  • RNA, Messenger
  • Tissue Inhibitor of Metalloproteinase-1
  • Matrix Metalloproteinase 8
  • Matrix Metalloproteinase 9