Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87

Hematol Oncol Clin North Am. 2000 Dec;14(6):1353-66, x. doi: 10.1016/s0889-8588(05)70190-8.

Abstract

The French protocol LALA 87 was designed to compare three different postinduction strategies in adult acute lymphocytic leukemia (ALL): chemotherapy, autologous transplantation, and allogeneic transplantation. This trial demonstrated a significant superiority of allogeneic bone marrow transplantation (BMT) in high-risk ALL patients. Similarly, there was a trend in favor of autologous BMT over chemotherapy in those same patients. Allogeneic BMT was not superior to autologous BMT or chemotherapy in less aggressive leukemia (standard-risk ALL). Further improvements are warranted in the treatment of adult ALL. The authors' current ongoing study is stratifying patients to allocate them to regimens with risk-adapted treatment intensity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Belgium / epidemiology
  • Bone Marrow Transplantation*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • France / epidemiology
  • Humans
  • Immunophenotyping
  • Life Tables
  • Middle Aged
  • Multicenter Studies as Topic
  • Philadelphia Chromosome
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Prognosis
  • Remission Induction
  • Risk Factors
  • Salvage Therapy
  • Survival Analysis
  • Survival Rate
  • Transplantation, Autologous
  • Transplantation, Homologous
  • Treatment Outcome