Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):182-7. doi: 10.1073/pnas.98.1.182.

Abstract

The identification of clones within bacterial populations is often taken as evidence for a low rate of recombination, but the validity of this inference is rarely examined. We have used statistical tests of congruence between gene trees to examine the extent and significance of recombination in six bacterial pathogens. For Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus, the congruence between the maximum likelihood trees reconstructed using seven house-keeping genes was in most cases no better than that between each tree and trees of random topology. The lack of congruence between gene trees in these four species, which include both naturally transformable and nontransformable species, is in three cases supported by high ratios of recombination to point mutation during clonal diversification (estimates of this parameter were not possible for Strep. pyogenes). In contrast, gene trees constructed for Hemophilus influenzae and pathogenic isolates of Escherichia coli showed a higher degree of congruence, suggesting lower rates of recombination. The impact of recombination therefore varies between bacterial species but in many species is sufficient to obliterate the phylogenetic signal in gene trees.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Bacteria / classification
  • Bacteria / genetics*
  • Bacteria / pathogenicity
  • Base Sequence
  • Genes, Bacterial / genetics
  • Genetic Variation / genetics
  • Genotype
  • Kinetics
  • Molecular Sequence Data
  • Mutagenesis / genetics
  • Phylogeny*
  • Point Mutation / genetics
  • Recombination, Genetic*
  • Statistics as Topic
  • Transformation, Bacterial

Associated data

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