Abstract
Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8(+) T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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CD8-Positive T-Lymphocytes / immunology*
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HLA-B35 Antigen / physiology
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Humans
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Leukocyte Common Antigens / analysis
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Parvovirus B19, Human / immunology*
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Viral Nonstructural Proteins / immunology
Substances
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HLA-B35 Antigen
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Viral Nonstructural Proteins
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Leukocyte Common Antigens