Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds

Carbohydr Res. 2000 Oct 6;328(4):611-5. doi: 10.1016/s0008-6215(00)00137-3.

Abstract

Based on the known anti-metastasis activities of lactosides and galactosides, a galactosyl and a lactosyl trimannoside were prepared via the conventional Koenigs-Knorr and trichloroacetimidate methods, respectively. Through typical deblocking procedures, a tetrasaccharide alpha-D-Galp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 and a pentasaccharide beta-D-Galp-(1 --> 4)-beta-D-Glcp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 were obtained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Galactosides / chemical synthesis*
  • Glycosides / chemical synthesis*
  • Mannosides / chemistry
  • Molecular Sequence Data
  • Neoplasm Metastasis / prevention & control
  • Oligosaccharides / chemical synthesis
  • Oligosaccharides / chemistry

Substances

  • Antineoplastic Agents
  • Galactosides
  • Glycosides
  • Mannosides
  • Oligosaccharides
  • lactosides