Age-related differences in acute physiologic response to focal traumatic brain injury in piglets

S R Durham; R Raghupathi; M A Helfaer; S Marwaha; A C Duhaime

doi:10.1159/000028980

Age-related differences in acute physiologic response to focal traumatic brain injury in piglets

Pediatr Neurosurg. 2000 Aug;33(2):76-82. doi: 10.1159/000028980.

Authors

S R Durham¹, R Raghupathi, M A Helfaer, S Marwaha, A C Duhaime

Affiliation

¹ Department of Neurosurgery, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pa., USA. durhamsr@mail.med.upenn.edu

PMID: 11070433
DOI: 10.1159/000028980

Abstract

Introduction: The goal of the present study was to determine whether age-related differences in the acute physiologic response to scaled cortical impact injury contribute to differences in vulnerability to traumatic brain injury (TBI).

Methods: Heart rate (HR), mean arterial pressure (MAP), brain temperature (BrT) and cerebral blood flow (CBF) were measured in 22 piglets (7 of age 5 days, 8 of age 1 month, 7 of age 4 months) at baseline and for 3 h following scaled cortical impact injury.

Results: There were no age-dependent variations from baseline in HR, MAP or BrT following injury. CBF increased in the 5-day-old animals following injury while CBF in the 1- and 4-month-old animals decreased following injury (p = 0.0049).

Conclusion: CBF was shown to have a significant age-dependent response to TBI with the youngest animals exhibiting increased CBF following injury.

MeSH terms

Acute Disease
Age Factors
Animals
Body Temperature / physiology*
Brain / blood supply
Brain Injuries / physiopathology*
Cerebrovascular Circulation
Disease Models, Animal*
Female
Heart Rate / physiology*
Male
Swine