Vancomycin resistance is associated with serine-containing peptidoglycan in Enterococcus gallinarum

J Bacteriol. 2000 Nov;182(21):6228-32. doi: 10.1128/JB.182.21.6228-6232.2000.

Abstract

In Enterococcus gallinarum SC1, a low-level vancomycin-resistant strain, only monomeric muropentapeptides with a C-terminal D-alanine were detected after growth without vancomycin. In contrast, in SC1 induced by vancomycin, as well as in AIB39, a constitutive vancomycin-resistant strain, monomeric and dimeric muropentapeptides with a C-terminal D-serine were detected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Chromatography, High Pressure Liquid
  • Enterococcus / chemistry
  • Enterococcus / drug effects*
  • Peptidoglycan / analysis*
  • Peptidoglycan / chemistry
  • Serine / analysis
  • Vancomycin / pharmacology*
  • Vancomycin Resistance

Substances

  • Anti-Bacterial Agents
  • Peptidoglycan
  • Serine
  • Vancomycin