[Characteristics of epidemiological strains of influenza A virus (H3N2) isolate in 1997-1999. Virus A/Moscow/10/99--a candidate to become the vaccine strain]

A N Slepushkin; V T Ivanova; E I Burtseva; T A Oskerko; T N Volodina; S G Kuribko; L V Kolobukhina; M V Beda

[Characteristics of epidemiological strains of influenza A virus (H3N2) isolate in 1997-1999. Virus A/Moscow/10/99--a candidate to become the vaccine strain]

Vopr Virusol. 2000 Jul-Aug;45(4):22-4.

[Article in Russian]

Authors

A N Slepushkin, V T Ivanova, E I Burtseva, T A Oskerko, T N Volodina, S G Kuribko, L V Kolobukhina, M V Beda

PMID: 10971961

Abstract

Antigenic properties of influenza A(H3N2) viruses isolated during two epidemic seasons 1997-98 and 1998-99 in Russia are analyzed. All strains are antigenic variants of the reference strain A/Sydney/5/97. Characteristics of epidemic strain A/Moscow/10/99, proposed by WHO expert committee as vaccine strain for 1999-2000 have been studied. This strain, isolated on chick embryos, is characterized by high reproductive activity in chicken embryos with an infectious titer of 10(6) EID50/0.2 ml, easily adapts to MDCK culture, and has a thermostable hemagglutinin.

Publication types

English Abstract

MeSH terms

Animals
Antigens, Viral / immunology
Chick Embryo
Disease Outbreaks
Humans
Influenza A Virus, H3N2 Subtype*
Influenza A virus / immunology
Influenza A virus / isolation & purification*
Influenza Vaccines / immunology*
Influenza, Human / epidemiology
Influenza, Human / prevention & control
Influenza, Human / virology*
Moscow / epidemiology

Substances

Antigens, Viral
Influenza Vaccines