[Comparative clinical study on 5-FU concentrations for oral HCFU and i.v. 5-FU]

Gan To Kagaku Ryoho. 2000 Jul;27(7):1011-4.
[Article in Japanese]

Abstract

Using the cross-over method, the same patients were administered continuous intravenous injections of 5-FU and HCFU, an oral derivative of 5-FU widely used for breast and colon cancer in Japan. The pharmacokinetics of 5-FU in blood of both drugs were then compared. The AUC of the 5-FU concentration in blood of the HCFU 100 mg group tended to be higher than that in the 5-FU 250 mg group and lower than that in the 5-FU 500 mg group. There was, however, no statistically significant difference between the HCFU and 5-FU 250 mg groups (p = 0.3274), or between the HCFU and 5-FU 500 mg groups (p = 0.1921).

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Oral
  • Antineoplastic Agents / administration & dosage*
  • Breast Neoplasms / blood
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / mortality
  • Cross-Over Studies
  • Drug Administration Schedule
  • Female
  • Fluorouracil / administration & dosage*
  • Fluorouracil / analogs & derivatives*
  • Fluorouracil / pharmacokinetics*
  • Humans
  • Injections, Intravenous
  • Survival Rate

Substances

  • Antineoplastic Agents
  • carmofur
  • Fluorouracil